Antiepileptic Drug Interactions: A Clinical Guide - download pdf or read online

By Philip N Patsalos

ISBN-10: 1447124332

ISBN-13: 9781447124337

ISBN-10: 1447124340

ISBN-13: 9781447124344

Antiepileptic Drug Interactions: A scientific advisor, moment Edition offers a pocket-sized, systematic description of the main clinically correct drug interactions that ensue among AEDs and in addition among AEDs and non-AEDs. AEDs are provided alphabetically and through drug classification in 3 sections for simple entry: Drug interactions among AEDs; Drug interactions among AEDs and non-AEDs: Interactions affecting AEDs; and Drug interactions among AEDs and non-AEDs: Interactions plagued by AEDs.

Antiepileptic Drug Interactions: A scientific advisor, moment Edition can assist physicians make extra rational offerings whilst polytherapy regimens are indicated and may be of curiosity to all who deal with sufferers with epilepsy: neurologists and neurosurgeons, trainees in any respect degrees, common practitioners and epilepsy nurse specialists.

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Additional info for Antiepileptic Drug Interactions: A Clinical Guide

Example text

Only the microsomal form of epoxide hydrolase is involved in xenobiotic metabolism and plays an important role in the metabolism of carbamazepine, phenobarbital, and phenytoin. Epoxide intermediates have been implicated in teratogenic events and hypersensitivity reactions and in relation to carbamazepine, carbamazepine-10,11-epoxide is considered to be equipotent to carbamazepine and contributes both to its antiepileptic and adverse effects. , valproic acid and quetiapine inhibit its activity and increase plasma carbamazepine-10,11-epoxide levels while phenobarbital enhances its activity and decreases plasma carbamazepine-10,11-epoxide levels [28–30].

Triazolam . . . . . . . . . . . . . . . . . . Valnoctamide. . . . . . . . . . . . . . . . . Zolpidem . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . 399 399 399 400 400 400 400 400 401 401 402 402 402 402 403 403 403 403 404 404 404 405 405 405 Index. . . . . . . . . . . . . . . . . . . . . . 409 Introduction Epilepsy, which affects approximately 1 % of the world’s population, is a chronic disorder that usually persists for many years and often for a lifetime [1].

Aripiprazole . . . . . . . . . . . . . . . Asenapine. . . . . . . . . . . . . . . . Bromperidol . . . . . . . . . . . . . . . Clozapine . . . . . . . . . . . . . . . . Chlorpromazine . . . . . . . . . . . . . Fluphenazine . . . . . . . . . . . . . . Haloperidol . . . . . . . . . . . . . . . Olanzapine . . . . . . . . . . . . . . . Quetiapine . . . . . . . . . . . . . .

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Antiepileptic Drug Interactions: A Clinical Guide by Philip N Patsalos


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