By Roger Williams, Rex J. Polson, John G. O’Grady (auth.), Lajos Okolicsányi M.D., Géza Csomós M.D., Gaetano Crepaldi M.D. (eds.)
The contributions to this quantity conceal all facets of the review and administration of hepatobiliary ailment. The focal issues of the ebook encompass 3 state of the art summaries. the 1st of those bargains with the hugely topical challenge of liver transplants from the viewpoint of sufferer choice. the second one considers drug-induced liver harm in view of the truth that the liver is the most metabolic website for a couple of medicinal drugs. the ultimate precis bargains with liver and getting older: it asks even if the liver follows the getting older strategy of the host organisms and even if the liver of elderly liver transplant candidate donors should be compatible for grafting. other than those themes, the amount offers uncomplicated study on hepatic delivery mechanisms, intrahepatic cholestasis and gall-stone sickness, which serves as a historical past for the themes extra particularly about the overview of liver functionality. a lot of the ebook is then dedicated to the administration of the most common varieties of liver illnesses and their issues, akin to persistent energetic hepatitis, liver cirrhosis, portal high blood pressure, hepatic encephalopathy, hepatorenal syndrome, and ascites.
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Extra resources for Assessment and Management of Hepatobiliary Disease
Experientia 31: 306-307 46. Heimberg M, Goh EM, Klausner HA, Soler-Argilaga C, Weinstein I, Wilcox HG (1978) Regulation of hepatic metabolism of free fatty acids. Interrelationships among secretion of very low density lipoproteins, ketogenesis and cholesterogenesis. In: Dietschy JM, Gotto AM Jr, Onthro JA (eds) Disturbances in lipid and lipoprotein metabolism. American Physiologic Society, Washington, p 251 (Clinical physiology series) 47. Samuel D, Paris S, Ailhaud G (1976) Uptake and metabolism of fatty acids and analogues by cultured cardiac cells from chick embryo.
Paumgartner G, Reichen J (1975) Kinetics of hepatic uptake of unconjugated bilirubin. Clin Sci Mol Med 51: 169-176 6. Weisiger RA, Gollan JL, Ockner RK (1981) Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substrates. Science 211: 10481051 7. Forker EL, Luxon BA, Snell M, Shurmantine WO (1982) Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity. J Pharmacol Exp Ther 223: 342-347 8.
This finding suggests that negatively charged species are carried across the sinusoidal membrane against a negative-inside (around -30 mY) membrane potential . It is expected, therefore, that this energy barrier is overcome by a downhill chemical potential which is somehow maintained across the membrane. A number of mechanisms are operating in the cytoplasm to lower the free ligand concentration, e. , ligandin , metabolic transformation, and biliary excretion. Isolation of Putative Plasma Membrane Carriers for Organic Anions Liver plasma membrane contains specific binding sites for BSP [33, 34], which may be shown to compete with bilirubin .
Assessment and Management of Hepatobiliary Disease by Roger Williams, Rex J. Polson, John G. O’Grady (auth.), Lajos Okolicsányi M.D., Géza Csomós M.D., Gaetano Crepaldi M.D. (eds.)