Read e-book online Asthma: Structural Basis — Theophylline Today / Strukturelle PDF

By Prof. Dr. K. Morgenroth (auth.), Prof. Dr. med. Friedrich Kummer (eds.)

ISBN-10: 321182670X

ISBN-13: 9783211826706

ISBN-10: 3709175399

ISBN-13: 9783709175392

The structural alterations of the bronchial mucosa in bronchial asthma are effects of mobile interactions. they seem extra gradual than the latter, they usually shape the foundation for the irreversible part of the practical affliction. This underlines the significance of early antiinflammatory remedy. during this context, our curiosity in theophyllin as a modulator of irritation has been evoked lately, supported via the most recent in vitro and in vivo results.

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Additional resources for Asthma: Structural Basis — Theophylline Today / Strukturelle Grundlagen — Theophyllin heute

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Pang J, Chan HS, Sung JY (1989) Prevalance of asthma, atopy and bronchial hyperreactivity in bronchiectasis: a controlled study. Thorax 44: 948-951 18. Spry CJF (1988) in Eosinophils. Oxford, University Press, p 272 19. Clelland CA, Higgenbottam TW, Stewart S, Scott JP, Wallwwark J (1990) The histological changes in trans bronchial biopsy after treatment of acute lung rejection in heart lung transplantation. J Pathol 161: 105-121 20. Cockroft DW (1990) Bronchial hyperresponsiveness: In: Mygind N, Pipkom U, Dahl R (eds) Rhinitis and asthma.

In summary, BHR+ve normal subjects had lower numbers of T cells and antigen presenting cells, yet increased proportions of suppressive macrophages than those subjects not exhibiting bronchial hyperreactivity. Thus BHR can exist in the absence of inflammation and is associated with reduced immunologic activity. The integrated picture The results above demonstrate beyond any reasonable doubt that the presence of bronchial hyperreactivity within an individual is not dependent on that individual expressing a chronic inflammation within the bronchial wall.

The p values given were obtained using the Mann-Whitney U test 46 St. J. Lane and T. H. Lee Assessment at monoclonal staining on bronchial epithelium " Epithelium stained 70 60 50 40 30 20 10 .. 0003 NORMAL ASTHMATIC MOpe2) p-NS Fig. 6. Percentage of airway epithelium stained with a monoclonal anti-GM- CSF or control mouse IgG J myeloma protein MOPC21 in 11 asthmatic and 9 normal subjects The extent of staining, as quantitated by the hue saturation-intensity (HSI) colour image analysis, indicated that asthmatic airway epithelial cells stained more strongly with a polyclonal or a monoclonal antibody to GM-CSF than that of normal subjects.

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Asthma: Structural Basis — Theophylline Today / Strukturelle Grundlagen — Theophyllin heute by Prof. Dr. K. Morgenroth (auth.), Prof. Dr. med. Friedrich Kummer (eds.)

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