By Lori A. Erickson
Atlas of Endocrine Pathology offers a accomplished compendium of photomicrographs of universal and unusual entities in endocrine pathology. the amount contains histologic positive factors of ordinary positive aspects, reactive stipulations, hyperplasia, and tumors. the main precious diagnostic gains are illustrated to supply path and clues to the analysis of endocrine tumors. moreover, photomicrographs spotlight the main pertinent diagnostic positive aspects in difficult diagnoses in endocrine pathology.
Authored by means of a nationally and the world over well-known pathologist, Atlas of Endocrine Pathology is a crucial studying instrument for these changing into accustomed to the varied entities encountered in endocrine pathology and a priceless reference for training pathologists confronted with hard diagnoses in endocrine pathology.
Table of Contents
1 Thyroid Histology
3 Graves disorder (Diffuse Hyperplasia)
4 Thyroid Goiter
5 Papillary Thyroid Carcinoma
6 Hyalinizing Trabecular Tumor
7 Follicular Thyroid Neoplasms
8 Hurthle mobilephone Thyroid Neoplasms
9 Poorly Differentiated Thyroid Carcinoma
10 Anaplastic Thyroid Carcinoma
11 Tumors of C Cells
12 strange Thyroid Tumors
13 Metastases to Thyroid
14 Parathyroid Histology
15 Parathyroid Hyperplasia
16 Parathyroid Adenoma
17 Parathyroid Carcinoma
19 Metastases to Parathyroid
20 Adrenal Gland Histology
21 Adrenal Cysts
22 Adrenal Cortical Hyperplasia
23 Adrenal Cortical Adenoma
24 Adrenal Cortical Carcinoma
25 Adrenal Myelolipoma
26 Pheochromocytoma and Adrenal Medullary Hyperplasia
27 Ganglioneuroma and Neuroblastoma
28 strange Adrenal Tumors
29 Metastases to the Adrenal Gland
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Additional resources for Atlas of Endocrine Pathology (Atlas of Anatomic Pathology)
Although sporadic cases of cribriformmorular PTC occur, this variant often occurs in FAP, an autosomal dominant syndrome of gastrointestinal adenomas and carcinomas, endometrial cancer, and medulloblastomas . Patients with FAP may present with the cribriform-morular variant of PTC ; thus, patients diagnosed with cribriform-morular PTC should be evaluated for FAP Fig. 36 Cribriform-morular variant of papillary thyroid carcinoma. The cribriform areas in the cribriform-morular variant of PTC have arches and anastomosing bars of cells.
These tumors are aggressive, particularly if >30 % of the tumor is hobnail; however, even in those with less hobnail component, aggressive behavior may occur  Fig. 58 Hobnail variant of papillary thyroid carcinoma. The cells lining the papillae and follicles in this hobnail variant of PTC show loss of polarity with apically placed nuclei and clusters of atypical cells. The papillae lack fibrovascular cores and follicular structures that, when present, lack colloid. The papillary structures vary in size and are lined by atypical cells with increased nuclear-to-cytoplasmic ratios and apical nuclei producing a surface bulge (hobnail) .
The colloid in PTC often is darker than that of the surrounding thyroid parenchyma. The cytologic features are characteristic of PTC, with enlarged, irregular nuclei; nuclear clearing; intranuclear pink holes; and longitudinal nuclear grooves. The intranuclear holes are cytoplasmic invaginations of the cytoplasm that are eosinophilic, comprise >50 % of the nucleus, and show condensation around the periphery of the hole Classic PTC 35 Fig. 15 Classic papillary thyroid carcinoma. The papillae in this cystic PTC have fibrovascular cores and are lined by cells with characteristic features of PTC, including enlarged, irregular nuclei; nuclear clearing; intranuclear pink holes; and longitudinal nuclear grooves Fig.
Atlas of Endocrine Pathology (Atlas of Anatomic Pathology) by Lori A. Erickson