By Cyril Fisher (auth.)
Soft tissue tumors are a wide and heterogeneous team of tumors and pseudotumors with a spectrum of habit from benign to frankly malignant. This Atlas of sentimental Tissue Tumor Pathology offers an outline of reactive, pseudoneoplastic, benign and intermediate neoplasms, sarcomas and similar stipulations coming up in subcutaneous and deep delicate tissues. Emphasis is put on microscopic appearances with correlation with gross diagnostic findings the place proper. moreover, the immunohistochemical and molecular genetic positive aspects of the key delicate tissue tumor subtypes are provided. This compendium of sentimental tissue tumors illustrates nearly all of illnesses you will definitely come upon in surgical pathology.
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Extra resources for Atlas of Soft Tissue Tumor Pathology
Beta-catenin expression in pediatric fibroblastic and myofibroblastic lesions: a study of 100 cases. Pediatr Dev Pathol. 2009;12:292–6. Thway K, Fisher C, Sebire NJ. Pediatric fibroblastic and myofibroblastic lesions. Adv Anat Pathol. 2012;19:54–65. Yantiss RK, Nielsen GP, Lauwers GY, Rosenberg AE. Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery: a clinicopathologic study of five cases. Am J Surg Pathol. 2003;27:532–40. 4 Intermediate and Malignant Fibroblastic and Myoﬁbroblastic Tumors Some fibroblastic and myofibroblastic tumors are categorized as intermediate in the World Health Organization’s consensus classification of 2002.
41 Proliferative myositis. This lesion is characterized by large polygonal ganglion-like cells that have basophilic cytoplasm and prominent nucleoli; they also are similar to those found in proliferative fasciitis. Although some have, mitoses are not a feature (although they may be seen in the fasciitis-like stroma). The cells lack lineagespecific immunohistochemical markers and are considered modified fibroblasts Fig. 43 Fibrous hamartoma of infancy. The three components of this lesion, found in variable proportions, are differentiated adipose tissue, moderately cellular fibrous bands, and more cellular aggregates of short spindle or ovoid cells with scanty cytoplasm.
4 Mesenteric fibromatosis. This forms a mass that infiltrates the mesentery and the muscularis propria of the bowel wall Fig. 2 Fibromatosis. The cells have ovoid uniform nuclei with punctate nucleoli and variable amounts of amphophilic cytoplasm. Pleomorphism and necrosis are absent, but normal mitotic figures sometimes are seen. Mast cells are a typical feature Fig. 5 Mesenteric fibromatosis. 1 Intermediate Tumors 39 Fig. 6 Plantar fibromatosis. Plump epithelioid and spindle myofibroblasts are distributed in dense collagen.
Atlas of Soft Tissue Tumor Pathology by Cyril Fisher (auth.)