By Akhlaq A. Farooqui
It is turning into more and more glaring that the deficiency of n-3 fatty acids in nutrition is not just linked to cardiovascular ailments, but additionally interested in stroke, epilepsy and different neurological and neurodegenerative illnesses, corresponding to Alzheimer disorder, Parkinson ailment, and peroxisomal ailments. In his most recent ebook, Beneficial results of Fish Oil on Human Brain, Dr. Akhlaq A. Farooqui expands at the prestige and healing significance of n-3 fatty acids (major parts of fish oil) and their mediators in common mind and people with neurodegenerative and neuropsychiatric ailments. Farooqui offers the advantages of n-3 fatty acids on Western vitamin, that is enriched in n-6 fatty acids (major elements of vegetable oil) and will advertise the above neurological problems. The publication will current readers with innovative and complete info on metabolism and roles of neural membrane n-3 fatty acids.
Neuroscientists, clinicians, neurologists, neuropathologists, opthamologists, dietitians, and nutritionists will locate this e-book beneficial for figuring out the molecular foundation of n-3 fatty acids and their lipid mediators (resolvins and neuroprotectins) in neuroprotection in acute neural trauma (stroke, spinal wire trauma and head damage) and neurodegenerative diseases.
About the Author:
Dr. Akhlaq A. Farooqui is a pacesetter within the box of mind phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity. He has came across the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) and diacyl- and monoacylglycerol lipases in brains from sufferers with Alzheimer ailment. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and raises degrees of eicosanoids that could be on the topic of the lack of synapses in brains of sufferers with Alzheimer illness. Dr. Farooqui has released leading edge learn at the iteration and id of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by means of lipidomics. He has formerly authored 4 monographs: Glycerophospholipids in mind: Phospholipase A2 in Neurological Disorders (2007); Neurochemical points of Excitotoxicity (2008); Metabolism and features of Bioactive Ether Lipids in Brain (2008); and Hot themes in Neural Membrane Lipidology (2009). All monographs are released through Springer.
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Extra resources for Beneficial Effects of Fish Oil on Human Brain
It can be estimated by reproducible and standardized procedures. Many epidemiological studies support the view that n–3 or w–3 index is an important risk factor or biomarker for sudden cardiac death. The n–3 or w–3 index can assess the risk for sudden cardiac death and monitor therapy with EPA + DHA. , 2005; von Schacky and Harris, 2007; Harris, 2008). Recent intervention studies with EPA in patients at 16 1 Fish Oil and Importance of Its Ingredients in Human Diet high cardiovascular risk in Japan indicate that subjects rarely die by sudden cardiac death.
2002). 7–10 g/day), have been described by several investigators (Dyerberg and Bang, 1979; Bang and Dyerberg, 1980). Bleeding tendencies include prolonged cutaneous, nose, urinary tract, and obstetric bleedings (Dyerberg and Bang, 1979). Furthermore, Greenland Eskimos show reduced platelet in vitro aggregability, compared with Danish control subjects. This reduction in platelet function has been explained by a shift in eicosanoid metabolism when ARA (20:4n–6) is replaced by EPA (20:5n–3) in platelet membranes.
2003). , 2002). The n–3 fatty acids in brain protects against cognitive decline in healthy older people. , 2007; Farooqui, 2009). 2 Effect of Fish Oil on Neuritogenesis DHA promotes neuronal differentiation in rat embryonic hippocampal primary cultures. In vitro DHA deficiency can be produced by culturing hippocampal cells in chemically defined medium (Calderon and Kim, 2007). DHA supplementation restores DHA levels to the levels detected in freshly isolated hippocampus. DHA supplementation in hippocampal cultures induces morphological differentiation by increasing the population of neurons with more branches and longer neurites.
Beneficial Effects of Fish Oil on Human Brain by Akhlaq A. Farooqui