By Lester Packer
This distinct, cutting-edge reference provides an in depth account of the molecular mechanisms underlying the a number of features of biothiols-emphasizing the organic and medical implications of interactions among oxidants and biothiols.
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Additional resources for Biothiols in Health and Disease (Antioxidants in Health and Disease Series, 2)
The high concentration of glutathione in cells clearly indicates its general importance in metabolic and oxidative detoxification processes. In many ways, glutathione may be considered the master antioxidant molecule, a phrase that Alton Meister, one of the pioneers in glutathione research and a contributor to this volume, has used. Bolstering of glutathione by other thiols, both natural (such as a-lipoic acid) and synthetic (such as Ebselen and several other drugs), has been investigated as a therapeutic approach to the oxidative component of various pathologies.
The optimal intake of antioxidants provides a preventive measure against these hazards. 5. There is a great need for improvement in public awareness of the potential preventive benefits of antioxidant nutrient intake. There is overwhelming evidence that the antioxidant nutrients such as vitamin E, vitamin C, carotenoids, alpha-lipoic acid and others are safe even at very high levels of intake. 6. Moreover, there is now substantial agreement that governmental agencies, health professionals and the media should promote information transfer to the general public, particularly when evidence exists that benefits for human health and public expenditure are overwhelming.
This book is printed on acid-free paper. Copyright © 1995 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA Page iii SERIES INTRODUCTION In June of 1992, 17 international researchers in the field of free radical and antioxidant biology and preventive medicine met at the village of Saas Fee, Switzerland, and drew up the Saas Fee Declaration to recognize the importance of prevention in medicine and health.
Biothiols in Health and Disease (Antioxidants in Health and Disease Series, 2) by Lester Packer