By H Balner M.D. (auth.)
Acute radiation damage in guy has been amply reviewed long ago a long time (1-8). details for these stories used to be typically derived from the Hiroshima and Nagasaki adventure (3), from radiation injuries as a con series of checking out nuclear guns and the appliance of nuclear power (9-13) and from the intentional irradiation of sufferers, in general for the remedy of malignancies and/or as conditioning for transplantation (14-20). extra, a wide physique of information derived from animal experimentation has ended in wary extrapolations to the human state of affairs (14). An tricky evaluate facing early somatic results of radiation in a guy used to be released through UNSCEAR ) in 1962 (2). It was once supplemented in 1969 with the same rfile dealing often with radiation-induced chromosome aberra tions, the results of radiation at the fearful process and, radio-active infection of our environment through nuclear trying out (21). In a newer UNSCEAR document (1972) the most issues have been genetic results, carcinogenesis and results of radiation at the immune reaction (22). The early results of radiation in guy have been additionally expertly and comprehensively reviewed in a record through the U.S. nationwide learn Council in 1967 (23).
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Additional info for Bone Marrow Transplantation and Other Treatment after Radiation Injury: A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research)
27 types of offspring regarding the MHC: ac, ad, bc, and bd. Consequently, 25 % of all siblings will be MHC-identical. Inheritance of the various haplotypes can be demonstrated by serological and cellular methods. Identical sibs have the same serologically defined antigens and are MLR negative because they share the o-locus determinants of both parental haplotypes. Recapitulating: parents and offspring share one MHC haplotype, siblings share 0, one or two MHC haplotypes. Those sharing both haplotypes are called genotypically identical; they are the allogeneic host/donor combinations with optimal results in organ and bone marrow transplantation (table IV).
E~, allo- donors. Their case histories have been well documented (59, 133, 134) and can be summarized as follows. 2 MeV gamma-rays. Adapted from a toble which appeared in ref. 14 (poge 196). 43 . The victims thus became candidates for marrow grafts although the risks of transplanting marrow from unrelated donors was well recognized, already at that time. After a short observation period in Belgrade, the casualties were flown to Paris and treated by a team headed by Jammet and Mathe (59). ) was given before as well as after marrow transplantation.
B)mostly chemotherapy-resistant cases in the terminal phase of illness. OlO~O~s marrow a cells, data are still scarce and difficult to interpret ) . The literature describes mostly patients with hematological malignancies, who were given autologous marrow aspirated during remissions of their disease. Frequent failures of engraftment in those cases have been attributed to poor recovery of viable stem cells after thawing the frozen cell suspensions (114). Now that reliable methods have been developed to "measure" the proportion of viable stem cells in preserved marrow (124), the actual size of the cellular inoculum can be determined more accurately and better clinical results can be expected.
Bone Marrow Transplantation and Other Treatment after Radiation Injury: A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research) by H Balner M.D. (auth.)