Download e-book for iPad: Brain Tumors: Biology, Pathology and Clinical References by Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa

By Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)

ISBN-10: 3540558640

ISBN-13: 9783540558644

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ISBN-13: 9783540616221

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Additional info for Brain Tumors: Biology, Pathology and Clinical References

Example text

It is, therefore, understandable that the "predisposing" mutation, even if transmitted as a dominant trait, is in reality recessive at the cellular level. Cytogenetic investigations and studies carried out with restriction fragmentlength polymorphism (RFLP) analysis have led to the localization of the retinoblastoma locus (RBI) on the q14 band of chromosome 13 [458,459,768]. Thus the RB gene behaves as a suppressor or repressor of tumor development, or as an "antioncogene" [1725], and its loss or inactivation leads to the development of the tumor.

In fact, the only zone of the mammalian adult encephalon in which radially oriented fibers may be observed is the hypothalamus, which belongs to the phylogenetically older part of the encephalon [3128, 1938]. This finding may be interpreted as representing a phylogenetic residuum of the diffuse system of radial glia which is present in lower vertebrates [1392]. The cells of the ependymal covering of the third ventricle, which are provided with a long process reaching the subpial layer, are called "tanycytes" (Fig.

Interestingly, a second mechanism of VHL gene inactivation has been described in sporadic clear cell renal carcinomas, consisting in hypermethylation of exon 1 [1302]. Recent studies [770, 1668] have suggested a possible mechanism of action of the VHL tumor suppressor gene. The normal product of VHL gene was shown to inhibit the activity of the transcriptional elongation factor named elongin, binding to its subunits Band C. In patients harboring defective VHL genes, elongin is not negatively regulated by the VHL gene product, resulting in excessive elongation of transcription and a high transcript level of as yet unidentified target genes [1790].

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Brain Tumors: Biology, Pathology and Clinical References by Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)


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