By Frances P. Malley, Sarah E. Pinder, Anna Marie Mulliga
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Extra resources for Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology
Cytokeratin immunohistochemistry can be particularly helpful in resolving this differential diagnosis. Apocrine proliferations, as noted earlier, particularly in association with sclerosing adenosis, may be difficult to diagnose. In the limited sample received in a core biopsy, the large nuclei and prominent nucleoli may be mistaken for DCIS by the unwary. The archetypical FIGURE 3-7 Particularly in core biopsy samples, usual epithelial hyperplasia in a fibroadenoma may be misinterpreted as a more worrisome process, such as ADH or DCIS.
SUGGESTED READINGS The complete suggested readings list is available online at www. com. 3 Core Biopsy: Methodologies, Reporting, and Management Issues n Sarah E Pinder n Anna Marie Mulligan n Frances P O’Malley n INTRODUCTION There are some general principles in breast pathology histology that can be described, whether one is handling and reporting nonoperative/core biopsy samples, diagnostic open surgical biopsy samples, or therapeutic specimens. For any sample, optimal fixation and processing of tissue and high-quality hematoxylin and eosin (H&E)–stained sections are essential.
It is recommended that in such cases the pathologist does not make an unequivocal diagnosis and repeat core biopsy or diagnostic surgical open biopsy is obtained. The proportion of such nondiagnostic “atypical” cases is less with core biopsy than with fine needle aspiration cytology (see Chapter 1). A normal portion of tissue may be received; this may contain normal fat or fat and fibrous tissue only or may bear breast parenchymal structures. The components present should be noted in the histology report.
Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology by Frances P. Malley, Sarah E. Pinder, Anna Marie Mulliga