By Ignacio Martín-Loeches
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Eur Respir J 1990;3:752 - 759.  Corre F, Lellouch J, Schwartz D. Smoking and leucocyte counts: Results of an epidemiological study. Lancet 1971;2:632 - 634.  Van Eeden SF, Hogg JC. The response of human bone marrow to chronic cigarette smoking. Eur Respir J 2000;15:915 - 921.  Yeung MC, Buncio AD. Leukocyte count, smoking and lung function. Am J Med 1984;76:383 - 386.  Burnett D. , editor. Pulmonary defences 1997;WileyEurope. :113 - 126.  Rydell-Tormanen K, Uller L, Erjefalt JS.
However, recent studies have demonstrated that mean bacteria colony forming units per ml of sample (counted during quantitative sputum culture) are at least a log higher in exacerbations compared with those seen in the stable state (27). Further more, bacterial exacerbations such as these are characterized by a significant increase in pulmonary inflammation including neutrophil recruitment and can be identified by the presence of purulent sputum (147) which resolves with resolution of symptoms (148).
Measurement of the bronchial mucous gland layer; a diagnostic yardstick in chronic bronchitis. Thorax 1960;15:132 - 141.  Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxon OR, et al. The nature of small airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645 - 2653.  Graham NWH. The epidemiology of acute respiratoy infection in children and adults: A global perspective. Epidemiol Rev 1990;12:149 - 178.
Bronchitis by Ignacio Martín-Loeches