By Karim Fizazi
Filling a spot within the literature, this consultant offers specialist thoughts and learn on carcinoma of an unknown fundamental website (CUP). protecting the id, prognosis, and administration of CUP with illustrative and reader-friendly medical case examples, this reference is helping physicians deal with sufferers whose fundamental melanoma web site is tough to find and check.
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Additional resources for Carcinoma of an Unknown Primary Site
This last data may be explained by the fact that breast cancers from women older than 40 years old lose the SP1 DNA binding function necessary for PR gene expression. Alongside the increase in ER-positive tumors with increased age, the percentage of ER- and PR-negative tumors decreased with increasing age as did the fraction of ER-negative but PR-positive tumors (Durbecq et al. 2008; Molino et al. 2006). These latter tumor types, considered as more aggressive and of worse prognosis than the ER & PR negative ones, represent 12% of the highly aggressive ER- and HER2-negative breast cancer.
2006). The prognostic impact of the poorer stage distribution among older women thus seems to be counterbalanced by more favorable tumor biology. Moreover, slower growing tumors can remain undetected for long. Just like for the other age groups, there probably is much variability in aggressiveness of disease in older women, stressing the need for a better understanding of the tumor biology to improve prognostication and choice of therapy (Mandelblatt 2006). Large-scale genome analysis may help to define the prognostic profile of a tumor and identify molecular subtypes as a basis for potential therapeutic targets, specifically for the elderly (Anders et al.
Age at diagnosis has been shown to be an independent indicator of breast cancer prognosis and despite the fact that breast cancer incidence increases with the age of the patient, it is generally stated that older women develop cancer with a relatively slower growth rate and that their prognosis is therefore better than that of the general population. Several publications have reported that advanced age is associated with favorable biological features, including a higher proportion of estrogen receptor (ER)-positive tumors.
Carcinoma of an Unknown Primary Site by Karim Fizazi